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- SaGa Frontier
- Saturday Morning RPG
- Seirei Senshi Spriggan
- Sengoku Ace
- Septerra Core: Legacy of the Creator
- Serious Sam 2
- Shadow Force
- Shadow Warrior (1997)
- Shadow Warrior (2013)
- Shadow Warrior 2
- Star Wars: Knights of the Old Republic
- Star Wars: Knights of the Old Republic II: The Sith Lords
- Star Wars: The Old Republic
- Strife
- Super Hydlide
- Super Robot Wars 30